first_imgJake says relationship with Shaina ‘goes beyond physical attraction’ Jo Koy: My brain always wants to think funny Kobe Bryant shares which university he would have chosen for college CONTRIBUTED PHOTOGilas Pilipinas on Tuesday arrived in Tokyo, Japan for the Fiba World Cup qualifying.National team coach Chot Reyes snapped a photo of the squad on his Instagram account. Gilas takes on Japan on Friday.ADVERTISEMENT MOST READ Kiss-and-tell matinee idol’s conquests: True stories or tall tales? It’s too early to present Duterte’s ‘legacy’ – Lacson “Touchdown Tokyo #gilasWCQ,” he wrote. Steam emission over Taal’s main crater ‘steady’ for past 24 hours Coco’s house rules on ‘Probinsyano’ set Naturalized center Andray Blatche, four-time PBA Most Valuable Player June Mar Fajardo, and lead guard Jayson Castro lead the 15-man pool.Joining the three are veteran national team members Gabe Norwood, Calvin Abueva, and Japeth Aguilar, together with Raymond Almazan, Allein Maliksi, Troy Rosario, Kevin Alas, sophomores Roger Pogoy, Matthew Wright, Mac Belo, and Carl Bryan Cruz, and rookie Kiefer Ravena.Terrence Romeo missed the trip due to a knee injury.The duel between Gilas and Japan will be held at Komazawa Olympic Park General Sports Gymnasium in Tokyo.The team, then, flies back home to host Chinese Taipei on Nov. 27 at Smart Araneta Coliseum.ADVERTISEMENT Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Reyes is expected to name the final 12-man roster on Thursday.Sports Related Videospowered by AdSparcRead Next OSG plea to revoke ABS-CBN franchise ‘a duplicitous move’ – Lacson Don’t miss out on the latest news and information. Jake says relationship with Shaina ‘goes beyond physical attraction’ Margot Robbie talks about filming ‘Bombshell’s’ disturbing sexual harassment scene LATEST STORIES View commentslast_img read more

first_imgLegion of Griffins: 1-handed LB joins twin on Seahawks P16.5-M worth of aid provided for Taal Volcano eruption victims — NDRRMC Green group flags ‘overkill’ use of plastic banderitas in Manila Sto. Niño feast “I think that’s going to be a chip on his shoulder. He has something to prove,” he said. “Back in my time, when he lost to Matthew Wright for the [Heritage MVP] award, I know he felt bad because he also wanted to win and you could see that in our practices. He did get the Finals MVP, but in my mind, Brickman and Wright were co-MVPs.”“So with him not winning the award once more, coupled with Mono’s situation in the Finals, I believe people will really see how good Jason Brickman is,” said Vanguardia.Game 4 is on Monday, still at Stadium 29 in Bangkok.Sports Related Videospowered by AdSparcRead Next LATEST STORIES READ: Alapag ‘big fan’ of Brickman: ‘One of the smartest point guards I’ve seen’“I coached Jimmy when he was a rookie when we drafted him in Talk ’N Text,” he said. “Jimmy and Jason have similarities, especially with the leadership, ball handling, and they’re tough. Like Jimmy Alapag, you can just give Jason the ball and he knows what decisions to make.”Vanguardia, though, wonders how Brickman, who averaged 10.4 points, 10.3 assists, and 5.9 rebounds this season, was once again snubbed for the Heritage MVP award.“I was surprised why he wasn’t named as the Heritage MVP,” he said, as the award went to Chong Son Kung Fu’s Fil-Am reinforcement Mikh McKinney. “For me, he deserves the award. Brickman was there from the start whereas McKinney came in late. But that’s how the voting went and we can’t do anything about it.”Vanguardia believes that the snub will fuel Brickman’s game, especially with Mono Vampire on the brink of losing the ABL title after Alab took a 2-1 lead in their best-of-five championship series after a 99-93 win in Game 3 on Saturday.ADVERTISEMENT Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Truck driver killed in Davao del Sur road accident Scientists seek rare species survivors amid Australia flames Don’t miss out on the latest news and information. “You can see that he makes his teammates better,” Vanguardia proudly said. “You know how better Sam Deguara is, but it’s the trust the team is giving him, he’s the leader. He’s the one dictating their offense and you can see that he’s not shying away from the spotlight.”Vanguardia coached Brickman under the banner of the Westports Malaysia Dragons, where the team, alongside Fil-Canadian Matthew Wright, claimed the 2016 ABL title.FEATURED STORIESSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSAfter winning title, time for LA Tenorio to give back to Batangas folkSPORTSTim Cone, Ginebra set their sights on elusive All-Filipino crownSince then, the Fil-Am playmaker has continued his ascent in the regional league and has given himself another shot at winning a title, this time with the Thai side.Seeing how Brickman has evolved as a player, Vanguardia couldn’t help but compare the 26-year-old to PBA legend and now San Miguel Alab Pilipinas coach Jimmy Alapag. Jo Koy draws ire for cutting through Cebu City traffic with ‘wang-wang’ MOST READ Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Volcano watch: Island fissures steaming, lake water receding ‘Stop romanticizing Pinoy resilience’ Photo from ASEAN Basketball LeagueIf there’s one person who isn’t surprised with how good Jason Brickman is, it’s definitely Ariel Vanguardia.Vanguardia is happy that finally, the Filipino crowd is witnessing how special his former prized point guard is as he dazzles for Mono Vampire in the bright lights of the 2018 ASEAN Basketball League Finals.ADVERTISEMENT In fight vs corruption, Duterte now points to Ayala, MVP companies as ‘big fish’ View commentslast_img read more

first_imgKCCA FC are winless in their last three games in all competitions. (PHOTOS/File)Uganda Premier LeagueKCCA FC vs Bright StarsStarTimes Stadium, LugogoSaturday, 05-10-2019 @3pmKCCA FC will be desperate to return to winning ways when they host Bright Stars in the Uganda Premier League (UPL) on Saturday afternoon.After falling short in their quest for CAF Champions League football last weekend, the Kasasiros marked their UPL return with a disappointing loss to Tooro United.It was a hard one to take as they missed two penalties in the first half with both Mike Mutyaba and Allan Okello seeing their effort saved by Mehdi Kibirige.The Kasasiros could also not capitalize on their one man advantage as Tooro United’s captain Mike Kawooya was sent off for handling a goal bound effort.The result left KCCA FC 10th on the standings with six points from their first three games of the season.Earlier, they had defeated both Wakiso Giants FC and Busoga United, with both games ending 1-0.Despite the loss in Tooro, KCCA FC head coach Mike Mutebi is not worried as his side is performing ‘well’.“It was such a disappointing loss away to Tooro but ut is not something to worry about as the boys played well, said Mutebi ahead of Saturday’s game.“It was one of those games that a team is not meant to win no matter what.“We have a chance to re-write the wrongs against Bright Stars and i have no doubt my players will get the job done.“They (Bright Stars) are a good footballing team and i expected a good encounter.KCCA FC are expect to welcome back the duo of Steven Sserwadda and Anaku Sadat who were not part of the match-day squad on Wednesday due to fatigue. Mustafa Kizza and Muzamiru Mutyaba also missed the last game due to slight injuries and are both expected to return on Saturday. Jurua Hassan, Julius Poloto and Sadam Juma are still out with ling term injuries.For Bright Stars, they are currently the only side yet to win a game this season.Bright Stars are the only side yet to win a game this season.After six games, Muhammad Kiseka’s side have drawn three and lost as many.They are currently occupying 14th spot ahead of Police FC and Proline.However, the other two were docked three and six points respectively, highlighting how poor Bright Stars have been since the season started.Kiseka is already under pressure for results anf if things don’t change soon, he may become the first managerial casualty of the season.Match FactsThis will be the 13th meeting between the two sides since September 2013.In the previous 12 meetings, Bright Stars have not defeated KCCA FC with the Kasasiros winning 9 of those meetings and drawing the other 3.Last season, KCCA FC did a double over Bright Stars including a 2-0 victory in the reverse fixture.KCCA come into the game having lost only one of their last six games in all competitions (W3 D2).In the League, Mutebi’s side have lost only one of their last 12 encounters (W8 D3).At home, Mutebi’s side are usually strong and head into Saturday’s game having lost only one of their last 34 encounters (W27 D6).For Bright Stars, they are currently on a six game winless streak having lost three and drawn as many.Away from home, they have not won any of their last four games (D1 L3).The other games on Saturday-Busoga United vs SC Villa @1pm-Vipers SC vs Proline FC @4pm-URA FC vs BUL FC @4pm-Maroons FC vs Onduparaka FC @4pm-Tooro United FC vs Kyetume FC @4pm-Wakiso Giants vs Mbarara City FC @4pmComments Tags: bright starsKCCA FCMehdi KisekaMike MutebiTooro unitedtopUganda Premier Leaguelast_img read more

first_imgBy Des Bieler | The Washington PostWashington’s increasingly makeshift situation at quarterback has done nothing to end questions about why the team has been hesitant to sign Colin Kaepernick. For his part, the noted free agent was reported Sunday to be “ready and willing” to play for Washington.That’s according to Charles Robinson of Yahoo Sports, who cited “two sources close to the former NFL quarterback” in reporting that Kaepernick “would be willing to play for (Washington) as early as …last_img read more

first_img(Visited 42 times, 1 visits today)FacebookTwitterPinterestSave分享0 The living cell contains thousands of molecular machines converting energy into useful work. Here are just a few that were recently described in journal papers.Any given week in the Proceedings of the National Academy of Sciences (PNAS), one is likely to find at least a dozen papers about molecular machines in the cell. Papers about biochemistry usually outnumber those in any other field of science. As imaging techniques continue to improve, the study of cellular machines has thrived, giving scientists better looks at the workings of the cell at higher magnification and finer resolution. This trend shows no sign of stopping.Those who have seen the film Unlocking the Mystery of Life remember the bacterial flagellum—an outboard motor. They may also remember Jed Macosko saying that a cell has “thousands of machines.” Some of the better-known ones, like the rotary engine ATP synthase and the tightrope-walking dynein, may also be familiar. Let’s take a look at samples from this last week’s catalog of machines discussed in one journal, PNAS, to get a taste of the variety of equipment keeping every cell in operation.The peroxide sensor (PNAS): Hydrogen peroxide, a powerful oxidant, can damage cells. Some types of bacteria have a special machine, OxyR, with four large domains, that sense H2O2 molecules. When a peroxide molecule is captured, one domain of the machine undergoes a “large conformational change” that triggers the regulatory domains into action.Peroxisome splitter (PNAS): Peroxides, along other reactive oxygen species and long-chain fatty acids are disposed of in a molecular furnace called the peroxisome. This organelle, containing enzymes involved in many metabolic processes, is duplicated by fission, similar to cell division. A molecular scissors named Peroxin 11 is responsible for initiation of the process; the researchers discovered that it is also important for the final step, scission, producing the two daughter organelles. Interestingly, this machine is “conserved” [unevolved] from yeast to mammalians.”The shape shifter (PNAS): These authors introduce their machine by saying, “Cells constantly sense and respond to mechanical signals by reorganizing their actin cytoskeleton.” They describe how a force applied to the cell membrane triggers a burst of calcium ions that, in turn, triggers actin molecules around the nucleus to reorganize the skeleton. The actin filaments form a “perinuclear rim” that “may function as a kinetic barrier to protect genome integrity until cellular homeostasis is reestablished.”The volume control (PNAS): This machine is right in the back of your eyeballs. Retina pigment cells must control their volume; how do they do it? There’s a volume-activated anion channel (VRAC) able to respond to swelling by opening its gates to let out excess ions. When this machine breaks because of mutations, macular dystrophy can result.Powerstroke of the walker (PNAS): This paper says, “Kinesin molecular motors couple ATP turnover to force production to generate microtubule-based movement and microtubule dynamics.” The authors discuss kinesin-14 from fruit flies, and show how its conversion of ATP to motion during the powerstroke is more complicated than thought. Then they say, “These findings are significant because they reveal that the key principles for force generation by kinesin-14s are conserved [i.e., unevolved] from yeast to higher eukaryotes.”The thermostat (PNAS): A machine call DesK responds to temperature changes (“essential to cell survival”) by triggering a reversible “zipper” mechanism. In bacterial cells, the transmembrane machine switches its shape if the temperature rises on the outside, triggering additional motions on the inside that can switch on other machines that induce other molecular responses. “The reversible formation of a serine zipper represents a novel mechanism by which membrane-embedded sensors may detect and transmit signals.”The tightrope walker (PNAS): The two-legged robot dynein walks on tightropes of microtubules, carrying cargo around the cell. Its feet (actually called “heads” by biochemists) have to be able to attach to the microtubules, but can switch from one rope to another as they move. This team investigated what happens when tension is applied to the machine. They dynein will slide if applied in one direction, but fasten more firmly in the other direction. This response is regulated by four additional machines (AAA1-4) that each use ATP as well.The emergency squad (PNAS): One of the worst emergencies in a cell is when both strands of a DNA double helix snap; it can trigger death of the cell or serious malfunction, leading to disease or cancer. Cosmic rays, chemicals or failures in normal cell processes like transcription can cause double-stranded breaks. Fortunately, there’s an emergency response team named NHEJ (non-homologous end-joining) that knows what to do. The researchers used super-resolution microscopy to watch the team build long filaments at either side of the break as one step in the repair process.A machine is a device that converts energy into work—not just any work, but directed, useful, functional work. The authors of these and many other papers have no hesitation calling these proteins “machines” and “motors.” Scientists have known about enzymes and proteins for well over a century, but understanding that cells operate with actual machines only dates back about 20 years or so. This revelation—that life operates by thousands of tiny mechanical devices—surely deserves to be called one of the most astounding discoveries in the history of science.One might compare this discovery to zooming in on what happens when a building is built. Perhaps you’ve watched one of those time-lapse films of a construction project. From a distance, you see just the major features taking shape. If you had never seen such a process before, you might assume this is “just what happens” from time to time. Then, as you are given a series of telescopes with higher and higher resolution, with the ability to stop individual frames of the sequence, the true picture becomes increasingly clear. You find hundreds of people down there operating cranes, bulldozers, ropes, pulleys, ramps and trucks. As you zoom in closer, you see them working in squads, communicating with phones, shaking hands, pointing and responding to each other’s actions. Undoubtedly, your appreciation of what’s involved in construction of a building would grow dramatically.Now shrink that down a billion-fold. Since the first humans opened their eyes and beheld the living world, there was plenty to show design. But we were like the viewer of the construction project from miles away, unaware of the actual way things work. People understood their bodies and the actions of animals or growth of plants at a macro level only: the running of a deer through a forest, the joy of eating good food and the necessity of disposing of waste, the act of sex and the birth of a child. When layers inside the body became exposed on the hunt, or through injury, a little more of the complexity would be apparent. But without detailed knowledge of what makes a heart beat, or what a liver or kidney actually does, these still might be taken for granted. Except for occasional insights from classical scholars like Aristotle, Hippocrates and Galen, the history of modern medicine and physiology only goes back a few centuries out of the thousands of years man has existed. Modern science starting the zoom-in view on the construction view. Leeuwenhoek opened the world’s eyes to the microbial world; he was astonished to see some of them dancing about with elegant motions.Fast-forward to about 1995 to the present. We are privileged to live in an age of unprecedented discovery, where our view has zoomed in to the range of billionths of a meter. What did we find? Just fluids jostling about, undergoing chemical reactions? No! A thousand times no! We found machines at work in factories, interacting with incredible efficiency. We found libraries of digital code. We found machines reading the code, translating it, and converting it into other machines. We found thermostats, walking robots, rotary engines, emergency response squads, and long-distance communication networks. We found temperature sensors, volume sensors, disposal services, packaging services, and defense systems. Sex was no longer the transfer of a featureless fluid from the male to the female, but a process of unbelievable complexity involving swimming robots carrying gigabytes of information to be joined to a very complex egg cell with more gigabytes of information, triggering a cascade of machines building machines all the way to a complete baby. The growth of a seedling into a plant is no longer to be shrugged off as something that happens from time to time in nature, but a complex interplay of hormones triggering changes to thousands of molecular machines in plant cells. It’s a planet of machinery! Look around and consider how every living organism, from the worm in the soil, to the bee pollinating a flower, to the hummingbird in the garden, to the tree growing higher and higher in your back yard, operates through the action of thousands of molecular machines that we have begun to understand only in the last tenth of 1% of recorded human history.If the wonder of what we have discovered doesn’t make you shout “Praise the Lord!” as never before, you might be asleep or dead.Tragically, praise has been the last thing on the minds of many scientists studying these things. A century and a half of Darwinian dogma has blinded their minds to the obvious inference to intelligent design from molecular machines. We find, however, some curious things in these papers. One is the frequent use of “remarkable” by the authors when they uncover something wonderful. Another is the increasing silence about Darwinism as more details come to light. (There’s an inverse relationship between the frequency of evolution-words to the amount of detail in scientific papers about molecular machines.) A third curious thing is biomimetics: i.e., how cellular machines inspire thoughts of copying those designs for human applications. Together, these curiosities in PNAS and other journals hint that the consciences of evolutionary biologists are not completely dead. A flicker of the design inference still burns and may catch fire some day. When it does, it could burn away the Darwinian chaff, liberate philosophy to once again celebrate natural design as real and pervasive, and provide rational grounds for people of understanding in academia to shout unrestrained, “Great is the Lord, and greatly to be praised!“Any of us can be ahead of our time and do that right now.last_img read more

first_img2 December 2008 Zangqa had scored out wide on the right, leaving captain Mzwandile Stick with a difficult conversion. He made it, however, to send the game into extra time to determine a winner. They’ll have a chance to win their tenth crown over the weekend of 5 December on home soil in George. Tickets are still available for the George event through Computicket outlets. SA coach Paul Treu said: “Our preparation was really good and the players all contributed superbly. Although this is a new look team, we still have a couple of players who won here in 2006 and who were part of our success early this year in Adelaide. With a first half performance that was almost faultless, the English ran in three converted tries to none to lead the Kiwis 21-0 at halftime. EnglandSouth Africa’s opponents in the final were England after they upset defending champions New Zealand in the semi-finals. TryAs time ticked down, it appeared that South Africa would bow out in the final four, but substitute Vuyo Zangqa broke from a scrum inside the Fijian 22-metre area and raced through for a try to pull South Africa within two points with only seconds remaining in the game. Stick added the extras and South Africa ran out 19-12 victors. England replied early in the second half with a try by Tom Biggs. The SA defence, however, kept him wide in the left hand corner and the conversion failed. The final was another hard-fought affair, but this time around South Africa didn’t have to come from behind. BreakTreu’s men seemed headed for extra time again, but with only 20 seconds remaining Gio Aplon broke from a ruck inside the South Africa 22-metre area. South Africa were thrust onto the back foot when Paul Delport was yellow carded and England took advantage of their numerical advantage when Nicky Young scored and then converted his own try to level the scores at 12-12. ‘Committed’“We were committed in defence and really took our chances at key moments,” he added. In Dubai, after running roughshod over their opposition in pool play – beating Scotland 31-10, the Arabian Gulf 33-0, and Kenya 31-0 – South Africa dealt comfortably with Australia in the quarterfinals, recording a 19-0 shutout.center_img Turning on the afterburners, he flew down the left-hand touchline, beating the despairing dive of England’s last defender before generously passing to Ryno Benjamin, so that he could score the try. Captain Mzwandile Stick said the unbeaten run of the Springboks on their end of season tour of the United Kingdom had served as motivation for his team; Bok coach Peter de Villiers was also on hand to present the Sevens team with their jerseys on Thursday, and then attended all their matches. A combination of a never-say-die attitude, patience, tough defence and execution carried South Africa to victory in the Dubai Sevens at the weekend. It was the second time in three years that South Africa have taken the honours in the event. In the extra period the captain once again stepped up to secure victory for his team with a sensational long distance dropped goal. The title was South Africa’s third in Dubai, after previous wins in 2003 and 2006. It was also their ninth IRB Series title in total. Right on halftime Mpho Mbiyozo crashed over to put South Africa 12-0 in front at the break. After the break, the New Zealanders fought back with a vengeance, matching the three tries of England, but when one of those went unconverted the champions were out. Early leadSA Rugby’s Young Player of the Year Robert Ebersohn put SA into an early lead when he cut inside and sliced through the England defence, which had been stretched by sustained attacks deep inside their half. Stick converted to increase the lead to 7-0. The second half followed the pattern of the first half with excellent defence from both sides snuffing out one attack after another. FijiFiji, in the semi-finals, were a much tougher proposition. The islanders tried to use their big men to drive the ball up and suck in the South African defenders before passing the ball out wide; their line-up was considerably bigger than South Africa’s, but determined defence by Treu’s charges turned the contest into a back-and-forth arm wrestle. Just before halftime, Fiji finally broke through when Rupeni Nasinga dotted down for a try, which was converted to put the Pacific islanders 7-0 clear at the break. Would you like to use this article in your publication or on your website? See: Using SAinfo materiallast_img read more

first_imgSouthface Energy Institute recently held a grand-opening ceremony for its new Southeast Weatherization Energy Efficiency Training Center, nicknamed the SWEET Center. The event was well attended, with several mercifully brief speeches by several dignitaries, including civil rights icon, Congressman John Lewis; officials from DOE and the Georgia Energy Office; and Atlanta Mayor Kasim Reed, who just the day before unveiled an ambitious sustainability plan for the city.After the ceremony, the center opened for tours, and competitions took place to see who could perform the best weatherization work on sample building sections. The classroom focuses on combustion safety issues, a big component of weatherization work, most of which is currently focused on low-income housing. My favorite display was the backdrafting demonstration, which uses theatrical fog machines to show exactly how easy it is to draw toxic fumes like carbon monoxide into a house with pressure imbalances. I want to shoot a video of this for some of my upcoming talks; it should scare the crap out of an audience.The center also includes several complete, albeit small homes, both indoors and out, that will be used to teach proper use of performance testing equipment. I liked the wall sections with clear plastic on one side that can be used to test blown insulation techniques. After students fill a stud cavity, they can see exactly how good a job they did, learning the best techniques in the process.We can’t outsource this workBob Adams, the DOE representative, shared some impressive statistics with the group. Stimulus funding is currently helping to weatherize more than 15,000 low-income homes every day; to date, almost a quarter of a million homes have been completed. In addition to providing training for low-income weatherization, one stated goal of this center is to expand the techniques to market-rate projects that will help our domestic economy grow. As many people have said, we can’t outsource weatherization work; it has to be done locally.last_img read more